PREMIUM | |
assay | 98% (HPLC) |
form | powder |
storage condition | desiccated |
protect from light | |
solubility | methanol: soluble10 mg/mL |
ethanol: soluble20 mg/mL (with heating) | |
originator | AstraZeneca |
storage temp. | 2-8C |
Gene Information | human ... ESR1(2099), ESR2(2100), ESRRG(2104), IL6(3569) rat ... Ar(24208), Esr1(24890), Esr2(25149) |
5, 25 mg in glass bottle
4-Hydroxytamoxifen (4-HT) is the active metabolite of tamoxifen which binds estrogen receptors (ER) and estrogen-related receptors (ERR) with estrogenic and anti-estrogenic effects. It is a cell permeable, selective estrogen receptor modulator (SERM). In Cas9 variants engineered with ligand-dependent inteins 4-Hydroxytamoxifen was used control Cas9 function, which reduced off target effects in CRISPR-mediated gene editing.