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()-Thalidomide
100 INR
Product Details:
- Melting Point 270 °C
- Molecular Formula C13H10N2O4
- Molecular Weight 258.23 Grams (g)
- Chemical Name ()-Thalidomide
- Purity(%) 99%
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()-Thalidomide Price And Quantity
- 100 INR
- 1 Kilograms
()-Thalidomide Product Specifications
- 99%
- C13H10N2O4
- ()-Thalidomide
- 258.23 Grams (g)
- 270 °C
()-Thalidomide Trade Information
- Cash in Advance (CID) Cash Advance (CA)
- 500 Kilograms KG Per Month
- 2-8 Week
- Yes
- Sample costs shipping and taxes has to be paid by the buyer
- Carton and Poly Bag.
- Western Europe Australia Eastern Europe Central America Africa Middle East South America Asia North America
- All India
Product Description
()-Thalidomide
-
Synonym: S()-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
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Empirical Formula (Hill Notation): C13H10N2O4
Molecular Weight: 258.23
CAS Number: 841-67-8
assay
| >98% | |
| form | solid |
| optical activity | []23/D 62.6°, c = 2 in DMF(lit.) |
| color | white |
| solubility | DMSO: soluble |
| H2O: insoluble | |
| ethanol: insoluble | |
| originator | Celgene |
| Gene Information | human ... LITAF(9516), TNF(7124) mouse ... Nos2(18126) rat ... Nos1(24598) |
Description
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor (TNF-); inhibitor of angiogenesis. (S)-Thalidomide is a teratogenic enatiomer.
Packaging
10 mg in poly bottle
25, 100 mg in glass bottle
Preparation Note
(-)-Thalidomide is soluble in DMSO, but is insoluble in water and ethanol.
Application
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis[1]. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos[2].
Features and Benefits
This compound was developed by Celgene.Enter Buying Requirement Details
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