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(+)-Thalidomide
100 INR
Product Details:
- Molecular Formula C13H10N2O4
- Molecular Weight 258.23
- Density 1.6±0.1 g/cm3
- Melting Point 273-276°C
- Appearance White Solid
- Chemical Name (+)-Thalidomide
- Purity(%) 99%
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(+)-Thalidomide Price And Quantity
- 1 Kilograms
- 100 INR
(+)-Thalidomide Product Specifications
- White Solid
- 273-276°C
- C13H10N2O4
- (+)-Thalidomide
- 99%
- 1.6±0.1 g/cm3
- 258.23
(+)-Thalidomide Trade Information
- Cash in Advance (CID) Cash Advance (CA)
- 500 Kilograms KG Per Month
- 2-8 Week
- Yes
- Sample costs shipping and taxes has to be paid by the buyer
- Carton and Poly Bag.
- Western Europe Central America Africa Middle East South America Australia Asia Eastern Europe North America
- All India
Product Description
(+)-Thalidomide
-
Synonym: R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
-
Empirical Formula (Hill Notation): C13H10N2O4
Molecular Weight: 258.23
CAS Number: 2614-06-4
assay
| 98% (HPLC) | |
| form | powder |
| color | white to beige |
| solubility | DMSO: soluble15 mg/mL, clear |
| originator | Celgene |
| storage temp. | room temp |
| Gene Information | human ... LITAF(9516), TNF(7124) mouse ... Nos2(18126) rat ... Nos1(24598) |
Description
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor (TNF-). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.
Preparation Note
Thalidomide is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml. It is insoluble in ethanol and water.
Application
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis[1]. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos[2].
Features and Benefits
This compound was developed by Celgene.
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