Synonym: (S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride
Linear Formula: C10H7OCH2CH(OH)CH2NHCH(CH3)2·HCl
Molecular Weight: 295.80
CAS Number: 4199-10-4
assay
98% (TLC) | |
form | powder |
optical activity | []25/D 25.5°, c = 1.0 in ethanol(lit.) |
mp | 193-195 °C(lit.) |
solubility | ethanol: soluble10 mg/mL |
DMSO: <14.5 mg/mL | |
H2O: soluble50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.) | |
45% (w/v) aq 2-hydroxypropyl--cyclode | |
originator | AstraZeneca |
storage temp. | 2-8C |
Gene Information | human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355) |
100, 500 mg in glass bottle
Active -adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites