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(S)-(+)-Camptothecin
100 INR
Product Details:
- Molecular Formula C20H16N2O4
- Molecular Weight 348.352 Grams (g)
- Melting Point 275 to 277 C (527 to 531 F)
- Boiling point 757.060.0 C at 760 mmHg
- Usage As a result of these efforts, two camptothecin analogs have been approved for cancer therapy: Topotecan (hycamtin) is approved for the treatment of recurring ovarian cancer, small cell lung cancer, and in combination with cisplatin for cervical cancer; irinotecan (camptosar) is prescribed for advanced cancers of the ...
- Chemical Name Camptothecin
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(S)-(+)-Camptothecin Price And Quantity
- 100 INR
- 1 Kilograms
(S)-(+)-Camptothecin Product Specifications
- 757.060.0 C at 760 mmHg
- 275 to 277 C (527 to 531 F)
- 348.352 Grams (g)
- C20H16N2O4
- As a result of these efforts, two camptothecin analogs have been approved for cancer therapy: Topotecan (hycamtin) is approved for the treatment of recurring ovarian cancer, small cell lung cancer, and in combination with cisplatin for cervical cancer; irinotecan (camptosar) is prescribed for advanced cancers of the ...
- Camptothecin
(S)-(+)-Camptothecin Trade Information
- Cash in Advance (CID) Cash Advance (CA)
- 500 Kilograms KG Per Month
- 2-8 Week
- Yes
- Sample costs shipping and taxes has to be paid by the buyer
- Carton and Poly Bag.
- Western Europe Australia Eastern Europe Middle East Central America Africa South America Asia North America
- All India
Product Description
(S)-(+)-Camptothecin
-
Empirical Formula (Hill Notation): C20H16N2O4
Molecular Weight: 348.35
CAS Number: 7689-03-4
assay
90% (HPLC) form powder mp 260 C (dec.)(lit.) solubility chloroform/methanol (4:1): soluble5 mg/mL Mode of action DNA synthesis | interferes enzyme | inhibits storage temp. 2-8C Gene Information human ... TOP1(7150)
mouse ... Prkca(18750)
rat ... Sstr2(54305)
Description
Other Notes
20S isomer
Packaging
1 g in glass bottle
100, 250 mg in glass bottle
Biochem/physiol Actions
(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
Features and Benefits
This compound is a featured product for Apoptosis research.
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