()-PPHT hydrochloride

• Synonym: ()-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434

• • Empirical Formula (Hill Notation): C₂₁H₂₇NO HCl

  • Molecular Weight: 345.91

  • CAS Number: 71787-90-1

assay  

Description

Biochem/physiol Actions

Potent D₂ dopamine receptor agonist.

A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of ()-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 (()-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.

Features and Benefits